Notice ID: 75N92024R0245
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Description
The overall aim of this renewal is to continue the FHS as a scientific resource for the research community to expand knowledge about the determinants of health and disease in heart, lung, blood, and sleep disorders. The overall goals of this acquisition are to (1) enhance statistical power to perform analyses of predictors of clinical events; (2) study the progression of risk factors with aging; and (3) identify new risk factors or interactions between risk factors that inform disease pathophysiology and/or disease progression. The operational goals are to (1) continue retention, annual follow-up, and clinical event ascertainment of all FHS study participants; (2) maintain FHS data and biospecimen repositories and facilitate use of FHS data and biospecimens; and (3) conduct a limited clinical examination of the FHS participants as a platform for investigator-initiated ancillary studies. The funds for a limited clinical examination will be awarded in this contract at the discretion of NHLBI and will be considered only if there is an ancillary study successfully funded. Should a limited clinical examination be funded, the Contractor shall work closely with ancillary study investigators to coordinate exam components from multiple funding sources.
